C

M

CAPULA , Mjriam

Last name: CAPULA

First name: Mjriam

2017 (v1)

Publication

Metadata-only

SGK1 affects RAN/RANBP1/RANGAP1 via SP1 to play a critical role in pre-miRNA nuclear export: A new route of epigenomic regulation

Dattilo, Vincenzo D'Antona, Lucia Talarico, Cristina

The serum- and glucocorticoid-regulated kinase (SGK1) controls cell transformation and tumor progression. SGK1 affects mitotic stability by regulating the expression of RANBP1/RAN. Here, we demonstrate that SGK1 fluctuations indirectly modify the maturation of pre-miRNAs, by modulating the equilibrium of the RAN/RANBP1/RANGAP1 axis, the main...

Uploaded on: April 14, 2023