CARABALLO RODRÍGUEZ , Isidoro

Dual-nozzle fused deposition modeling (FDM) is a 3D printing technique that allows for the simultaneous printing of two polymeric filaments and the design of complex geometries. Hence, hybrid formulations and structurally different sections can be combined into the same dosage form to achieve customized drug release kinetics. The objective of...

Stimuli-responsive polymersomes have emerged as smart drug delivery systems for programmed release of highly cytotoxic anticancer agents such as doxorubicin hydrochloride (Dox·HCl). Recently, a biodegradable redox-responsive triblock copolymer (mPEG–PDH–mPEG) was synthesized with a central hydrophobic block containing disulfide linkages and two...

Problem based Learning (PBL) is a technique for educational innovation that has the advantage of turning the student into an active part of the teaching-learning process. Our experience at the Faculty of Pharmacy of the University of Seville indicates that students who participate in any group of PBL, in a subject that is explained following a...

Ultrasound assisted compression (USAC) is a manufacturing technique which applies thermal and mechanical energy to the powder bed, producing tablets with improved characteristics compared to the direct compression process. This technology is ideal for thermoplastic materials, as polyurethanes, whose particles usually undergo a sintering...

Ultrasound-assisted compression (USAC) is a technology combining a conventional compression process and US irradiation. These mechanical and thermal effects lead to heating, melting and sintering of materials. This article reviews the principles of ultrasound-assisted compression and its main applications in pharmaceutical technology. Physical...

Percolation theory is a multidisciplinary theory that studies chaotic systems. It has been applied in the pharmaceutical field since 1987. The application of this theory to study the release and hydration rate of hydrophilic matrices allowed for first time to explain the changes in release and hydration kinetic of swellable matrices type...

Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs. Fused Deposition Modeling (FDM) highlights among other 3D technologies due to its low cost and easy to operate but, until now, it has the drawbacks...

Objetivo: Analizar la farmacoterapia de dos grupos de pacientes esquizofrénicos de la Fundación Andaluza para la Integración Social del Enfermo Mental (FAISEM) en Sevilla, atendiendo a la medicación concomitante al tratamiento antipsicótico. Método: Se ha examinado la historia farmacoterapéutica de todos los pacientes esquizofrénicos de...

Stereolitograpy (SLA) is an optical photosolidification technology, which can be used to produce 3D printed dosage forms. In the present work, the model drug 4-Aminosalicylic was combined with the photopolymer poly(ethylene glycol) diacrylate (PEGDA), the plasticizer poly(ethylene glycol) (PEG) and the photoinitiator diphenyl(2,4,6-...

Fractal dimension has been employed for the first time to provide key information about the behaviour of extruded filaments. High drug loaded filaments made of thermoplastic polyurethane and anhydrous theophylline (10–70% w/w of drug content) have been obtained by using a single screw extruder. Fractal analysis was carried out based on the...

Objetivo: Analizar la farmacoterapia de dos grupos de pacientes esquizofrénicos de la Fundación Andaluza para la Integración Social del Enfermo Mental (FAISEM) en Sevilla, atendiendo al tratamiento antipsicótico. Método: Se ha estudiado la historia farmacoterapéutica de todos los paciente esquizofrénico de "Casas-Hogar" (CH) y "Viviendas...