CARLA VILLA

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Fenretinide (N-(4-hydroxyphenyl)-retinamide, 4-HPR) is a synthetic retinoid with fewer adverse effects than natural retinoids, effective against ovarian, prostate, small cell lung, brain, neuroectodermal-derived tumors. Clinical responses in adult and pediatric patients are often partial, revealing a limited activity of 4-HPR against existing...

Organogels are semi-solid systems in which a three-dimensional network, composed by the organgelator fibers, immobilizes an organic liquid phase by twisting around it. They find application in different industrial fields as "soft" materials; their mechanical and chemical properties, together with their rheological behavior, make them excellent...

La metodologia Life Cycle Assessment (LCA) è lo strumento più usato per valutare le performance ambientali di prodotti, processi e servizi, poiché l'identificazione e la quantificazione degli impatti ambientali viene eseguita secondo correlazioni scientifiche causa-effetto e la standardizzazione fornita dalle norme UNI EN ISO 14040:2006 e UNI...

Retinoblastoma is a rare, sometimes hereditary, pediatric cancer. In high-income countries this disease has a survival rate approaching 100%, while in low- and middle-income countries the prognosis is fatal for about 80% of cases. Depending on the stage of the disease, different therapeutic protocols are applied. In more advanced forms of the...

Nanotechnology is an important application in modern cancer therapy. In comparison with conventional drug formulations, nanoparticles ensure better penetration into the tumor mass by exploiting the enhanced permeability and retention effect, longer blood circulation times by a reduced renal excretion and a decrease in side effects and drug...

The aim of this work was the development of polymeric films from polysaccharides, containing olive mill wastewater (OMW) as antibacterial agent [1], for skin injures and wound healing. An optimal wound dressing should be nontoxic, non-adherent, non-allergenic, it should also maintain a wet medium at the wound interfacing and be easily removed...

Here, to develop new topical antibacterial formulations to treat staphylococcal infections, two pyrazoles (3c and 4b) previously reported as antibacterial agents, especially against staphylococci, were formulated as hydrogels (R1-HG-3c and R1HG-4b) using a cationic polystyrene-based resin (R1) and here synthetized and characterized as gelling...

This work focuses on the clinical‐organizational model implemented in an Italian region (Liguria) to streamline the access procedures to galenic cannabis preparations. The competent local health care authority that takes care of tracing a virtuous path to obtain common, uniform and shared protocols and ensure high standards of care is A.Li.Sa....

The indole heterocycle represents one of the most important scaffolds in medicinal chemistry and is shared among a number of drugs clinically used in different therapeutic areas. Due to its varied biological activities, high unique chemical properties and significant pharmacological behaviors, indole derivatives have drawn considerable interest...

Fenretinide (4-HPR), a synthetic retinoid with low toxicological profile, is endowed with high an-titumor activity. However, 4-HPR shows poor oral absorption due to its low solubility, and variable blood concentrations for a massive hepatic first pass effect. Here, we prepared nanoparticles (NPs) made of 4-ammoniunbutylstyrene random copolymer...

Fenretinide (N-(4-hydroxyphenyl)-retinamide, 4-HPR) is a synthetic retinoid with fewer adverse effects than natural retinoids, whose efficacy against ovarian, prostate, small cell lung, brain, neuroectodermal-derived tumors has been widely demonstrated in several in vitro and preclinical studies. Unfortunately, clinical responses both in adult...