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CARLEVARIS , Onintza

Last name: CARLEVARIS

First name: Onintza

September 23, 2022 (v1)

Publication

Metadata-only

Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Martí, Juan Manuel Garcia-Diaz, Angel Delgado-Bellido, Daniel

Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expression/ activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness breast/ovarian cancer and have been shown to regulate the hypoxic response; therefore, their use could...

Uploaded on: March 24, 2023
2019 (v1)

Journal article

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SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer

Zubiete-Franco, Imanol García-Rodríguez, Juan Lopitz-Otsoa, Fernando

Background: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).Methods: Herein we have overexpressed LKB1 in human hepatoma cells and by using histidine pull-down assay we...

Uploaded on: December 4, 2022