C

I

CARMONA CUENCA , Irene

Last name: CARMONA CUENCA

First name: Irene

December 16, 2016 (v1)

Publication

Metadata-only

Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model

Jiménez Muñoz, Sebastián Torres Canalejo, Manuel Vizuete Chacón, María Luisa

Neurotrophins, activating the PI3K/Akt signaling pathway, control neuronal survival and plasticity. Alterations in NGF, BDNF, IGF-1, or insulin signaling are implicated in the pathogenesis of Alzheimer disease. We have previously characterized a bigenic PS1xAPP transgenic mouse displaying early hippocampal Aβ deposition (3 to 4 months) but late...

Uploaded on: March 25, 2023
February 2, 2015 (v1)

Publication

Metadata-only

Defective lysosomal proteolysis and axonal transport are early pathogenic events that worsen with age leading to increased APP metabolism and synaptic Abeta in transgenic APP/PS1 hippocampus

Gutiérrez Pérez, Antonia Vitorica Ferrández, Francisco Javier Dávila Cansino, José Carlos

Background: Axonal pathology might constitute one of the earliest manifestations of Alzheimer disease. Axonal dystrophies were observed in Alzheimer's patients and transgenic models at early ages. These axonal dystrophies could reflect the disruption of axonal transport and the accumulation of multiple vesicles at local points. It has been also...

Uploaded on: March 27, 2023