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CAROLA , G.

Last name: CAROLA

First name: G.

November 16, 2022 (v1)

Publication

Metadata-only

Parkinson's disease patient-specific neuronal networks carrying the LRRK2 G2019S mutation unveil early functional alterations that predate neurodegeneration

Carola, G. Malagarriga, D. Calatayud, C.

A deeper understanding of early disease mechanisms occurring in Parkinson's disease (PD) is needed to reveal restorative targets. Here we report that human induced pluripotent stem cell (iPSC)-derived dopaminergic neurons (DAn) obtained from healthy individuals or patients harboring LRRK2 PD-causing mutation can create highly complex networks...

Uploaded on: March 24, 2023