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CARPER , Deborah

Last name: CARPER

First name: Deborah

October 11, 2024 (v1)

Journal article

Metadata-only

Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity

Carper, Deborah Lac, Marlène Coue, Marine

Type 2 diabetes (T2D) and obesity are strongly associated with low natriuretic peptide (NP) plasma levels and a down-regulation of NP guanylyl cyclase receptor-A (GCA) in skeletal muscle and adipose tissue. However, no study has so far provided evidence for a causal link between atrial NP (ANP)/GCA deficiency and T2D pathogenesis. Here, we show...

Uploaded on: October 24, 2024