Con el desarrollo postnatal se producen transformaciones morfofuncionales que permiten a las motoneuronas (Mns) extraoculares adultas generar la actividad necesaria para producir los movimientos y fijaciones oculares. Las modificaciones electrofisiológicas y morfológicas que cursan con el desarrollo en Mns del núcleo motor ocular común (nMOC),...
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March 14, 2017 (v1)PublicationUploaded on: December 4, 2022
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April 10, 2017 (v1)Publication
The neuronal input–output function depends on recruitment threshold and gain of the firing frequency–current (f–I) relationship. These two parameters are positively correlated in ocular motoneurons (MNs) recorded in alert preparation and inhibitory inputs could contribute to this correlation. Phasic inhibition mediated by γ-amino butyric acid...
Uploaded on: December 4, 2022 -
February 27, 2015 (v1)Publication
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Uploaded on: March 27, 2023 -
July 13, 2016 (v1)Publication
The mammalian oculomotor nucleus receives a strong γ-aminobutyric acid (GABA)ergic synaptic input, whereas such projections have rarely been reported in fish. In order to determine whether this synaptic organization is preserved across vertebrates, we investigated the GABAergic projections to the oculomotor nucleus in the goldfish by combining...
Uploaded on: December 4, 2022 -
September 20, 2022 (v1)Publication
Neurodegenerative diseases are characterized by gradually progressive, selective loss of anatomically or physiologically related neuronal systems that produce brain damage from which there is no recovery. Despite the differences in clinical manifestations and neuronal vulnerability, the pathological processes appear to be similar, suggesting...
Uploaded on: December 5, 2022 -
February 7, 2024 (v1)Publication
It has been claimed that oxidative stress and the production of reactive oxygen radicals can contribute to neuron degeneration and might be one factor in the development of different neurological diseases. In our study, we have attempted to clarify how oxidative damage induces dose dependent changes in functional membrane properties of neurons...
Uploaded on: February 11, 2024 -
March 3, 2021 (v1)Publication
Oxidative stress is one of the main proposed mechanisms involved in neuronal degeneration. To evaluate the consequences of oxidative stress on motor cortex pyramidal neurons during postnatal development, rats were classified into three groups: Newborn (P2–P7); infantile (P11–P15); and young adult (P20–P40). Oxidative stress was induced by 10 µM...
Uploaded on: March 26, 2023 -
December 4, 2023 (v1)Publication
La presente invención escribe un método electrofisiológico y un kit consistente en una concentración de 10 µM de hidroperóxido de cumeno puro en líquido cefalorraquídeo para cuantificar los efectos de la toxicidad sobre las propiedades intrínsecas de las neuronas de la corteza motora a los 5 minutos de exposición a la acción tóxica y su uso en...
Uploaded on: December 6, 2023 -
March 2, 2022 (v1)Publication
Vitamin D is an essential fat-soluble vitamin that participates in several homeostatic functions in mammalian organisms. Lower levels of vitamin D are produced in the older population, vitamin D deficiency being an accelerating factor for the progression of the aging process. In this review, we focus on the effect that vitamin D exerts in the...
Uploaded on: December 4, 2022 -
February 15, 2021 (v1)Publication
Glioblastoma (GBM) is the most common form of brain tumor characterized by its resistance to conventional therapies, including temozolomide, the most widely used chemotherapeutic agent in the treatment of GBM. Within the tumor, the presence of glioma stem cells (GSC) seems to be the reason for drug resistance. The discovery of GSC has boosted...
Uploaded on: March 26, 2023 -
January 26, 2022 (v1)Publication
Achieving the distinctive complex behaviors of adult mammals requires the development of a great variety of specialized neural circuits. Although the development of these circuits begins during the embryonic stage, they remain immature at birth, requiring a postnatal maturation process to achieve these complex tasks. Understanding how the...
Uploaded on: December 4, 2022 -
April 26, 2021 (v1)Publication
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis is low. It is therefore necessary to identify new therapeutic targets to fight GBM...
Uploaded on: December 4, 2022 -
April 19, 2022 (v1)Publication
Hippocampal neurogenesis has widely been linked to memory and learning performance. New neurons generated from neural stem cells (NSC) within the dentate gyrus of the hippocampus (DG) integrate in hippocampal circuitry participating in memory tasks. Several neurological and neuropsychiatric disorders show cognitive impairment together with a...
Uploaded on: March 25, 2023 -
May 23, 2022 (v1)Publication
Neuroinflammation underlies neurodegenerative diseases. Herein, we test whether acute colon inflammation activates microglia and astrocytes, induces neuroinflammation, disturbs neuron intrinsic electrical properties in the primary motor cortex, and alters motor behaviors. We used a rat model of acute colon inflammation induced by dextran...
Uploaded on: December 4, 2022 -
June 6, 2023 (v1)Publication
Harmonic mechanisms orchestrate neurogenesis in the healthy brain within specific neurogenic niches, which generate neurons from neural stem cells as a homeostatic mechanism. These newly generated neurons integrate into existing neuronal circuits to participate in different brain tasks. Despite the mechanisms that protect the mammalian brain,...
Uploaded on: June 7, 2023