En 1951, Falconer describió por primera vez un tipo de ratones mutantes espontáneos a los que denominó reeler, los cuales presentaban una mutación autosómica recesiva que les provocaba anormalidades arquitectónicas severas en la corteza cerebral. En 1995 se clonó el gen que codifica la Reelina y se descubrió que el ratón "reeler" no expresaba...
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March 7, 2017 (v1)PublicationUploaded on: March 27, 2023
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April 8, 2019 (v1)Publication
Reelin is an extracellular matrix protein first known for its key role in neuronal migration. Studies in rodent small intestine suggested that reelin protects the organism from intestinal pathology. Here we determined in mice colon, by real time-PCR and immunological assays, the expression of the reelin signalling system; its response to...
Uploaded on: December 4, 2022 -
November 11, 2022 (v1)Publication
Previous observations made in human and mouse colons suggest that reelin protects the colon from pathology. In this study, we evaluated reelin expression during the transition from either colitis or precancerous lesions to colon cancer and tried to elucidate reelin regulation under these transition processes. Samples of healthy and pathological...
Uploaded on: March 24, 2023 -
April 8, 2019 (v1)Publication
We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis. The aim of the current study was to determine whether reelin protects from colorectal cancer and how reelin defends from colon pathology. In the colon of...
Uploaded on: December 4, 2022 -
November 4, 2022 (v1)Publication
Instituto de Salud Carlos III CM19/00051, CD19/00143, FI19/00298
Uploaded on: March 24, 2023 -
July 14, 2022 (v1)Publication
Parkinson's disease is a highly prevalent neurological disorder for which there is currently no cure. Therefore, the knowledge of risk factors as well as the development of new putative molecular targets is mandatory. In this sense, peripheral inflammation, especially the originated in the colon, is emerging as a predisposing factor for...
Uploaded on: March 25, 2023