CASAS DELGADO , Marta

Ultrasound assisted compression (USAC) is a manufacturing technique which applies thermal and mechanical energy to the powder bed, producing tablets with improved characteristics compared to the direct compression process. This technology is ideal for thermoplastic materials, as polyurethanes, whose particles usually undergo a sintering...

Stimuli-responsive polymersomes have emerged as smart drug delivery systems for programmed release of highly cytotoxic anticancer agents such as doxorubicin hydrochloride (Dox·HCl). Recently, a biodegradable redox-responsive triblock copolymer (mPEG–PDH–mPEG) was synthesized with a central hydrophobic block containing disulfide linkages and two...

Three-dimensional printing has become a feasible manufacturing technique for pharmaceutical products providing cheap and accurate freeform systems with a great potential for personalized-dose drugs. Fused Deposition Modeling (FDM) highlights among other 3D technologies due to its low cost and easy to operate but, until now, it has the drawbacks...

Stereolitograpy (SLA) is an optical photosolidification technology, which can be used to produce 3D printed dosage forms. In the present work, the model drug 4-Aminosalicylic was combined with the photopolymer poly(ethylene glycol) diacrylate (PEGDA), the plasticizer poly(ethylene glycol) (PEG) and the photoinitiator diphenyl(2,4,6-...

Fractal dimension has been employed for the first time to provide key information about the behaviour of extruded filaments. High drug loaded filaments made of thermoplastic polyurethane and anhydrous theophylline (10–70% w/w of drug content) have been obtained by using a single screw extruder. Fractal analysis was carried out based on the...

There are many factors influencing the drug release behaviour from a pharmaceutical formulation as the particle size of the drug and excipient, porosity of the system or geometrical phase transitions of the components. Therefore, the choice of the adequate excipient to achieve a specific drug release profile is mainly based on the experience...

In the last few years, the employment of 3D printing technologies in the manufacture of drug delivery systems has increased, due to the advantages that they offer for personalized medicine. Thus, the possibility of producing sophisticated and tailor-made structures loaded with drugs intended for tissue engineering and optimizing the drug dose...

Colonic drug delivery of drugs is an area of great interest due to the need to treat high prevalence colonic local diseases as well as systemic conditions that may benefit from the advantages associated to this route of drug administration. In the last decade, the use of 3D printing technologies has expanded, offering the possibility of...

The current regulatory environment based on the ICH guidelines encourages a systematic and science-based approach in the pharmaceutical development, required by the "Quality by design" concept. This methodology implies that the quality of a product must be designed instead of assayed in the final dosage form. For this purpose, a deep knowledge...

The use of 3D printing technology in the manufacturing of drug delivery systems has expanded and benefit of a customized care. The ability to create tailor-made structures filled with drugs/delivery systems with suitable drug dosage is especially appealing in the field of nanomedicine. In this work, chitosan-based polymeric micelles loaded with...

Thermoplastic polyurethanes (TPU) offer excellent properties for a wide range of dosage forms. These polymers have been successfully utilized in personalized medicine production using fused deposition modeling (FDM) 3D printing (3DP). However, direct powder extrusion (DPE) has been introduced recently as a challenging technique since it...

La presente invención tiene por objeto el uso de la Lcarnitina, sus sales y derivados en productos cosméticos dermatológicos, preferentemente dentro del campo técnico del tratamiento cosmético de todos los tipos de estrías y cicatrices superficiales de mamíferos, preferentemente el hombre, como consecuencia de la actividad antifibrótica de la carnitina.

La presente invención se refiere a conjugados del chitosan (o sus derivados) con tiolactonas (síntesis y estructuras químicas), en las composiciones cosméticas, biomédicas-farmacéuticas que contienen dichos conjugados, y a sus aplicaciones, que presentan las siguientes propiedades: no tóxicos, biodegradables, con excelentes propiedades de...