CASTELLANO POZO , Maikel

Para el mantenimiento y el control de los procesos celulares, la integridad genética es un factor clave. Mutaciones o factores que alteren este control, conllevan a la inestabilidad del genoma, provocando defectos tanto a nivel celular como a nivel de organismo (Aguilera y Gómez-Gonzalez, 2008). Uno de los mecanismos clave para la integridad...

The integrity of the genome is crucial for the survival of all living organisms. However, genomes need to adapt to survive certain pressures, and for this purpose use several mechanisms to diversify. Chromosomal instability (CIN) is one of the main mechanisms leading to the creation of genomic heterogeneity by altering the number of chromosomes...

THO is a conserved eukaryotic complex involved in mRNP biogenesis and RNA export that plays an important role in preventing transcription- and RNA-mediated genome instability in mitosis and meiosis. In mammals THO is essential for embryogenesis, which limits our capacity to analyze the physiological relevance of THO during development and in...