Airways are lined by a pseudostratified mucociliated epithelium which is mainly composed of basal, goblet and multiciliated cells harboring hundreds of motile cilia at their apical part. Their coordinated beating allows the expulsion of inhaled particles that get trapped in the mucus. Following tissue lesions, the epithelium must regenerate,...
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May 29, 2020 (v1)PublicationUploaded on: December 4, 2022
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March 2020 (v1)Journal article
Pathological remodeling of the airway epithelium is commonly observed in cystic fibrosis (CF). Thus, tissue repair is critical to restore integrity and maintenance of the epithelial barrier function. Epithelial repair is a multi-step process initiated by progenitor cell migration into the injured area, proliferation, and re-differentiation into...
Uploaded on: December 4, 2022 -
2017 (v1)Journal article
miR-34/449 microRNAs are conserved regulators of multiciliated cell differentiation. Here, we evidence and characterize expression of two isomiR variant sequences from the miR-34/449 family in human airway epithelial cells. These isomiRs differ from their canonical counterparts miR-34b and miR-449c by one supplemental uridine at their 5 0-end,...
Uploaded on: December 4, 2022 -
2017 (v1)Journal article
miR-34/449 microRNAs are conserved regulators of multiciliated cell differentiation. Here, we evidence and characterize expression of two isomiR variant sequences from the miR-34/449 family in human airway epithelial cells. These isomiRs differ from their canonical counterparts miR-34b and miR-449c by one supplemental uridine at their 5 0-end,...
Uploaded on: February 22, 2023 -
June 2023 (v1)Journal article
The MIR449 genomic locus encompasses several regulators of multiciliated cell (MCC) formation (multiciliogenesis). The miR-449 homologs miR-34b/c represent additional regulators of multiciliogenesis that are transcribed from another locus. Here, we characterized the expression of BTG4, LAYN, and HOATZ, located in the MIR34B/C locus using...
Uploaded on: September 5, 2023