CAVIGLIA G.

Compartmental analysis is the mathematical framework for the modelling of tracer kinetics in dynamical Positron Emission Tomography. This paper provides a review of how compartmental models are constructed and numerically optimized. Specific focus is given on the identifiability and sensitivity issues and on the impact of complex physiological...

In this paper we propose a new algorithm to optimize the parameters of a compartmental problem describing tumor hypoxia. The method is based on a multivariate Newton approach, with Tikhonov regularization, and can be easily applied to data with diverse statistical distributions. Here we simulate [18F]-fluoromisonidazole Positron Emission...

We prove a Cayley–Bacharach type theorem for points in projective space (Formula presented.) that lie on a complete intersection of (Formula presented.) hypersurfaces. This is made possible by new bounds on the growth of the Hilbert function of almost complete intersections.

We introduce the notion of E-depth of graded modules over polynomial rings to measure the depth of certain Ext modules. First, we characterize graded modules over polynomial rings with (sufficiently) large E-depth as those modules whose (sufficiently) partial general initial submodules preserve the Hilbert function of local cohomology modules...

We estimate the Castelnuovo-Mumford regularity of ideals in a polynomial ring over a field by studying the regularity of certain modules generated in degree zero and with linear relations. In dimension one, this process gives a new type of upper bounds. By means of recursive techniques this also produces new upper bounds for ideals in any dimension.