CEBALLOS CHÁVEZ , María

No description

Biosynthesis of transfer RNA requires processing from longer precursors at the 5′- and 3′-ends. In eukaryotes, in archaea, and in those bacteria where the 3′-terminal CCA sequence is not encoded, 3′ processing is carried out by the endonuclease RNase Z, which cleaves after the discriminator nucleotide to generate a mature 3′-end ready for the...

Chromatin distribution is not uniform along the human genome. In most genes there is a promoter-associated nucleosome free region (NFR) followed by an array of nucleosomes towards the gene body in which the first (+1) nucleosome is strongly positioned. The function of this characteristic chromatin distribution in transcription is not fully...

Tudor domain containing protein 9 (TDRD9) is a RNA helicase normally expressed in the germline, where it is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). Here, we show that TDRD9 is highly expressed in a subset of non-small cell lung carcinomas and derived cell lines by hypomethylation of its CpG island. Furthermore, TDRD9...