CECILIA MARINI

Bone remodeling requires a delicate balance between bone-forming osteoblasts and bone-resorping osteoclasts. However, in pathological conditions, bone remodeling is often deregulated and the uncoupling of osteoclasts and osteoblasts functions may alter the extent of bone loss. Although in Chronic Lymphocytic Leukemia (CLL) patients macroscopic...

The cross-kingdom stress hormone abscisic acid (ABA) and its mammalian receptors LANCL1 and LANCL2 regulate the response of cardiomyocytes to hypoxia by activating NO genera tion. The overexpression of LANCL1/2 increases transcription, phosphorylation and the activity of eNOS and improves cell vitality after hypoxia/reoxygenation via the...

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Significant skeletal alterations are present in Chronic Lymphocytic Leukemia (CLL) patients; bone erosion, particularly evident in the long bone shaft, appeared increased in the progressive disease stage. Moreover, the partial colonization of the bone with reactive bone marrow we documented via PET-FDG imaging suggests that neoplastic cell...