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CENCI , Maria Angela

Last name: CENCI

First name: Maria Angela

July 7, 2023 (v1)

Publication

Metadata-only

Apoptosis-inducing factor mediates dopaminergic cell death in response to LPS-induced inflammatory stimulus: Evidence in Parkinson's disease patients

Burguillos García, Miguel Ángel Hajji, Nabil Englund, Elisabet

We show that intranigral lipopolysaccharide (LPS) injection, which provokes specific degeneration of DA neurons, induced caspase-3 activation in the rat ventral mesencephalon, which was mostly associated with glial cells. In contrast, nigral DA neurons exhibited AIF nuclear translocation in response to LPS. A significant decrease of the...

Uploaded on: July 8, 2023