CERDAN , Rachel

Last name: CERDAN

First name: Rachel

April 13, 2015 (v1)

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Plasmodium falciparum CTP:phosphocholine cytidylyltransferase possesses two functional catalytic domains and is inhibited by a CDP-choline analog selected from a virtual screening

Contet, Alicia Pihan, Émilie Lavigne, Marina

International audience

Uploaded on: December 4, 2022
April 18, 2023 (v1)

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Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion

Lohia, Rakhee Allegrini, Benoit Berry, Laurence

An inherited gain-of-function variant (E756del) in the mechanosensitive cationic channel PIEZO1 was shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) infection by Plasmodium falciparum is prevented by the pharmacological activation of PIEZO1. Yoda1 causes an increase...

Uploaded on: May 14, 2023
February 15, 2013 (v1)

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Biochemical characterization of Plasmodium falciparum CTP:phosphoethanolamine cytidylyltransferase shows that only one of the two cytidylyltransferase domains is active

Maheshwari, Sweta Lavigne, Marina Contet, Alicia

International audience

Uploaded on: December 4, 2022
June 2, 2021 (v1)

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Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion

Lohia, Rakhee Le Guet, Jordy Berry, Laurence

Abstract An inherited gain-of–function variant (E756 del) in the mechanosensitive cationic channel PIEZO1 was recently shown to confer a significant protection against severe malaria. Here, we demonstrate in vitro that human red blood cell (RBC) infection by Plasmodium falciparum is prevented by the pharmacological activation of PIEZO1. The...

Uploaded on: December 4, 2022

CERDAN , Rachel

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