CHAINTREUIL , Paul

Macrophages are immune cells resulting from embryogenesis or from the differentiation of monocytes. Schematically, three populations of macrophages co-exist: naive macrophages (M0), pro-inflammatory macrophages (M1) and anti-inflammatory macrophages (M2 or immunosuppressive). Naive macrophages have phagocytic functions and recognize pathogens...

Macrophages are widely distributed innate immune cells that play an indispensable role in a variety of physiologic and pathologic processes, including organ development, host defense, acute and chronic inflammation, solid and hematopoietic cancers. Beyond their inextricable role as conveyors of programmed cell death, we have previously...

CSF-1 and IL-34 share the CSF-1 receptor and no differences have been reported in the signaling pathways triggered by both ligands in human monocytes. IL-34 promotes the differentiation and survival of monocytes, macrophages and osteoclasts, as CSF-1 does. However, IL-34 binds other receptors, suggesting that differences exist in the effect of...

International audience