C

S

CHAOUCH , Soraya

Last name: CHAOUCH

First name: Soraya

June 2021 (v1)

Journal article

Metadata-only

Role of human group IIA secreted phospholipase A2 in malaria pathophysiology: Insights from a transgenic mouse model

Dacheux, Mélanie Chaouch, Soraya Joy, Alonso

We previously showed that injection of recombinant human group IIA secreted phospholipase A2 (hGIIA sPLA2) to Plasmodium chabaudi-infected mice lowers parasitaemia by 20%. Here, we show that transgenic (TG) mice overexpressing hGIIA sPLA2 have a peak of parasitaemia about 30% lower than WT littermates. During infection, levels of circulating...

Uploaded on: December 4, 2022