TMP21 has been shown to be associated with the gamma-secretase complex and can specifically regulate gamma-cleavage without affecting epsilon-mediated proteolysis. To explore the basis of this activity, TMP21 modulation of gamma-secretase activity was investigated independent of epsilon-cleavage using an APPepsilon construct which lacks the...
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August 25, 2009 (v1)Journal articleUploaded on: December 4, 2022
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June 20, 2008 (v1)Journal article
The presenilin (PS)-dependent gamma-secretase activity refers to a high molecular mass-complex including, besides PS1 or PS2, three other proteins recently identified, namely nicastrin, Aph-1, and Pen-2. This proteolytic complex has been shown to contribute to both gamma- and epsilon-cleavages of the beta-amyloid precursor protein (betaAPP),...
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July 16, 2004 (v1)Journal article
International audience
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October 29, 2004 (v1)Journal article
International audience
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June 12, 2009 (v1)Journal article
Complexes involved in the gamma/epsilon-secretase-regulated intramembranous proteolysis of substrates such as the amyloid-beta precursor protein are composed primarily of presenilin (PS1 or PS2), nicastrin, anterior pharynx defective-1 (APH1), and PEN2. The presenilin aspartyl residues form the catalytic site, and similar potentially functional...
Uploaded on: December 3, 2022 -
September 30, 2005 (v1)Journal article
International audience
Uploaded on: December 4, 2022