CHIAPPALONE M.

Characterizing neuronal networks activity and their dynamical changes due to endogenous and exogenous causes is a key issue of computational neuroscience and constitutes a fundamental contribution towards the development of innovative intervention strategies in case of brain damage. We address this challenge by making use of a multimodular...

Dissociated cortical neurons in vitro display spontaneously synchronized, low-frequency firing patterns, which can resemble the slow wave oscillations characterizing sleep in vivo. Experiments in humans, rodents, and cortical slices have shown that awakening or the administration of activating neuromodulators decrease slow waves, while...

Behaviors, from simple to most complex, require a two-way interaction with the environment and the contribution of different brain areas depending on the orchestrated activation of neuronal assemblies. We used cultured networks coupled to MEAs (i.e. Micro Electrode Arrays) as a simplified model system to investigate the computational properties...

Behaviors, from simple to most complex, require a two-way interaction with the environment and the contribution of different brain areas depending on the orchestrated activation of neuronal assemblies. We used cultured networks coupled to MEAs (i.e. Micro Electrode Arrays) as a simplified model system to investigate the computational properties...

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Objective. Electroencephalography (EEG) cleaning has been a longstanding issue in the research community. In recent times, huge leaps have been made in the field, resulting in very promising techniques to address the issue. The most widespread ones rely on a family of mathematical methods known as blind source separation (BSS), ideally capable...

The development of in vitro neuronal models constituted by patterned networks is of significant interest in the neuroscientific community and requires the convergence of electrophysiological studies with micro/nano-fabrication techniques. In this paper we make use of a methodology to induce self-organization of networks into two connected...

Uniform and modular primary hippocampal cultures from embryonic rats were grown on commercially available microelectrode arrays to investigate network activity with respect to development and integration of different neuronal populations. Modular networks consisting of two confined active and inter-connected sub-populations of neurons were...

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In the past, tetanic stimulation has been used in several different instances to induce changes in the firing patterns of neural networks in vitro. In this paper, we ran a new experimental campaign to verify if this protocol induced lasting changes and if those changes were predictable. We found out that our stimulation protocol led to...