C

CHIOVITTI K.

Last name: CHIOVITTI K.

2010 (v1)

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Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation

CORSARO, ALESSANDRO THELLUNG DE COURTELARY, STEFANO VILLA, VALENTINA

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Uploaded on: March 31, 2023
2011 (v1)

Publication

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Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

VILLA, VALENTINA TONELLI, MICHELE THELLUNG DE COURTELARY, STEFANO

Quinacrine is one of the few molecules tested to treat patients affected by prion diseases, although the clinical outcome is largely unsatisfactory. To identify novel derivatives with higher neuroprotective activity, we evaluated the effects of a small library of acridine derivatives. The 6-chloro-2-methoxyacridine derivatives bearing on...

Uploaded on: April 14, 2023