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CHRISTMANN , Markus

Last name: CHRISTMANN

First name: Markus

2018 (v1)

Publication

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Inherent and toxicant-provoked reduction in DNA repair capacity: A key mechanism for personalized risk assessment, cancer prevention and intervention, and response to therapy

Kaina, Bernd Izzotti, Alberto Xu, Jianzhen

Genomic investigations reveal novel evidence which indicates that genetic predisposition and inherent drug response are key factors for development of cancer and for poor response to therapy. However, mechanisms for these outcomes and interactions with environmental factors have not been well-characterized. Therefore, cancer risk, prevention,...

Uploaded on: April 14, 2023
August 15, 2007 (v1)

Journal article

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Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells.

Rébillard, Amélie Tekpli, Xavier Meurette, Olivier

We have previously shown that cisplatin triggers an early acid sphingomyelinase (aSMase)-dependent ceramide generation concomitantly with an increase in membrane fluidity and induces apoptosis in HT29 cells. The present study further explores the role and origin of membrane fluidification in cisplatin-induced apoptosis. The rapid increase in...

Uploaded on: December 3, 2022