C

CHU C. C.

Last name: CHU C. C.

2017 (v1)

Publication

Metadata-only

The number of overlapping AID hotspots in Germline IGHV genes is inversely correlated with mutation frequency in chronic lymphocytic Leukemia

Yuan C. Chu C. C. Yan X. -J.

The targeting of mutations by Activation-Induced Deaminase (AID) is a key step in generating antibody diversity at the Immunoglobulin (Ig) loci but is also implicated in B-cell malignancies such as chronic lymphocytic leukemia (CLL). AID has previously been shown to preferentially deaminate WRC (W = A/T, R = A/G) hotspots. WGCW sites, which...

Uploaded on: April 14, 2023