C

CIARROCCHI A.

Last name: CIARROCCHI A.

2022 (v1)

Publication

Metadata-only

The spectrum of subclonal TP53 mutations in chronic lymphocytic leukemia: A next generation sequencing retrospective study

De Luca G. Cerruti G. Lastraioli S.

Chronic lymphocytic leukemia (CLL) is a hematological disorder with complex clinical and biological behavior. TP53 mutational status and cytogenetic assessment of the deletion of the corresponding locus (17p13.1) are considered the most relevant biomarkers associated with pharmaco-predictive response, chemo-refractoriness, and worse prognosis...

Uploaded on: February 7, 2024
2022 (v1)

Publication

Metadata-only

MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells

Matis S. Recchia A. G. Colombo M.

Chronic lymphocytic leukemia (CLL) cells express the interleukin-23 receptor (IL-23R) chain, but the expression of the complementary IL-12R(31 chain requires cell stimulation via surface CD40 molecules (and not via the B-cell receptor [BCR]). This stimulation induces the expression of a heterodimeric functional IL-23R complex and the secretion...

Uploaded on: February 11, 2024