C

E

CICHERO , E.

Last name: CICHERO

First name: E.

2023 (v1)

Publication

Metadata-only

In Silico and In Vitro Evaluation of the Mechanism of Action of Three VX809-Based Hybrid Derivatives as Correctors of the F508del CFTR Protein

Baroni, D. Scarano, N. Ludovico, A.

Cystic fibrosis (CF), the most common autosomal recessive fatal genetic disease in the Caucasian population, is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR), an anion channel that regulates salt and water transport across a variety of secretory epithelia. Deletion of phenylalanine at...

Uploaded on: February 25, 2024