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CICHERO , Elena

Last name: CICHERO

First name: Elena

2022 (v1)

Publication

Metadata-only

Virtual Screening in the Identification of Sirtuins' Activity Modulators

Abbotto, Elena Scarano, Naomi Piacente, Francesco

Sirtuins are NAD(+)-dependent deac(et)ylases with different subcellular localization. The sirtuins' family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins regulate a wide range of different processes, ranging from transcription to metabolism to...

Uploaded on: January 31, 2024
2016 (v1)

Publication

Metadata-only

Exhaustive 3D-QSAR analyses as a computational tool to explore the potency and selectivity profiles of thieno[3,2-: D] pyrimidin-4(3 H)-one derivatives as PDE7 inhibitors

Cichero, Elena Brullo, Chiara Bruno, Olga

The development of selective ligands binding to specific PDE isoforms represents an urgent need in medicinal chemistry, being a necessary strategy to identify many more drug-like compounds, to be investigated for several therapies. Concerning inflammation, rational design of selective PDE7 inhibitors over PDE4 could lead to derivatives endowed...

Uploaded on: April 14, 2023