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CIOTTI , Maria Teresa

Last name: CIOTTI

First name: Maria Teresa

2017 (v1)

Publication

Metadata-only

Extracellular truncated tau causes early presynaptic dysfunction associated with Alzheimer's disease and other tauopathies

Florenzano, Fulvio Veronica, Corsetti Ciasca, Gabriele

The largest part of tau secreted from AD nerve terminals and released in cerebral spinal fluid (CSF) is C-terminally truncated, soluble and unaggregated supporting potential extracellular role(s) of NH2-derived fragments of protein on synaptic dysfunction underlying neurodegenerative tauopathies, including Alzheimer's disease (AD). Here we show...

Uploaded on: April 14, 2023