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CIUFFREDA , Loreta Pia

Last name: CIUFFREDA

First name: Loreta Pia

2017 (v1)

Publication

Metadata-only

Upregulation of TH/IL-17 Pathway-Related Genes in Human Coronary Endothelial Cells Stimulated with Serum of Patients with Acute Coronary Syndromes

CIMMINO, Giovanni Ciuffreda, Loreta Pia Ciccarelli, Giovanni

Inflammation plays an essential role in the development and complications of atherosclerosis plaques, including acute coronary syndromes (ACS). Indeed, previous reports have shown that within the coronary circulation of ACS patients, several soluble mediators are released. Moreover, it has been demonstrated that endothelial dysfunction might...

Uploaded on: March 27, 2023
2013 (v1)

Publication

Metadata-only

Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells

MARTINELLI, Erika TROIANI, Teresa D'Aiuto, Elena

The RAS/RAF/MEK/MAPK and the PTEN/PI3K/AKT/mTOR pathways are key regulators of proliferation and survival in human cancer cells. Selective inhibitors of different transducer molecules in these pathways have been developed as molecular targeted anti-cancer therapies. The in vitro and in vivo anti-tumor activity of pimasertib, a selective MEK 1/2...

Uploaded on: April 14, 2023