COHEN , Alan

Alzheimer disease (AD) is a disastrous neurodegenerative disease for which presently noconsensus exists neither for the etiology nor for the efficacity of treatments. The amyloidhypothesis of the disease pathogenesis predominated during decades stating that amyloidbeta (Aβ) formation and oligomerization is the major cause for AD. Recently,...

Organismal ageing is associated with many physiological changes, including differences in the immune system of most animals. These differences are often considered to be a key cause of age-associated diseases as well as decreased vaccine responses in humans. The most often cited vaccine failure is seasonal influenza, but, while it is usually...

Clinically, Alzheimer's disease (AD) is a syndrome with a spectrum of various cognitive disorders. There is a complete dissociation between the pathology and the clinical presentation. Therefore, we need a disruptive new approach to be able to prevent and treat AD.