In several Hymenoptera, sexual fate is determined by the allelic composition at the complementary sex-determiner locus, a sex-determination mechanism that can strongly affect population dynamics. To date, the molecular identification of complementary sex determiner has only been achieved in the honeybee, where the complementary sex-determiner...
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2012 (v1)Journal articleUploaded on: December 4, 2022
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2014 (v1)Journal article
Most species in the order Hymenoptera are parasitoids that lay eggs and develop in or on the body of arthropod hosts. Several factors contribute to successful parasitism including venoms that wasps inject into hosts when ovipositing. Here, we review the composition, function and diversity of parasitoid venoms with emphasis on studies of wasps...
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2009 (v1)Journal article
The insect phenoloxidase (PO) cascade is known to be tightly regulated by serine proteases and serine protease inhibitors of the serpin family. As a key component of the insect immune system, it is also suspected to be inhibited by several endoparasitoid wasps, insects that develop inside other arthropods as hosts. However, the underlying...
Uploaded on: December 3, 2022 -
2011 (v1)Book section
This chapter reviews data available on parasitoid wasps' VLPs, mainly on the basis of their structure and composition. This leads to the discussion how to discriminate between virus-resembling VLPs and viruses, and to suggest that some of the VLPs might be cellular secreted vesicles, such as microvesicles and exosomes described in many...
Uploaded on: December 4, 2022 -
July 2021 (v1)Journal article
Temperature is particularly important for ectotherms, including endoparasitoid wasps that develop inside another ectotherm host. In this study, we tested the impact of three temperatures (20 °C, 25 °C and 30 °C) on the host–parasitoid immune interaction using two Drosophila host species (Drosophila melanogaster and D. yakuba) and two parasitoid...
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2007 (v1)Journal article
Inactivation of host Rho GTPases is a widespread strategy employed by bacterial pathogens to manipulate mammalian cellular functions and avoid immune defenses. Some bacterial toxins mimic eukaryotic Rho GTPase-activating proteins (GAPs) to inactivate mammalian GTPases, probably as a result of evolutionary convergence. An intriguing question...
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September 17, 2012 (v1)Conference paper
National audience
Uploaded on: December 4, 2022 -
February 10, 2014 (v1)Conference paper
National audience
Uploaded on: February 22, 2023 -
September 2015 (v1)Journal article
Understanding the forces that shape eco-evolutionary patterns often requires linking phenotypes to genotypes, allowing characterization of these patterns at the molecular level. DNA-based markers are less informative in this aim compared to markers associated with gene expression and, more specifically, with protein quantities. The...
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2021 (v1)Journal article
Female endoparasitoid wasps usually inject venom into hosts to suppress their immune response and ensure offspring development. However, the parasitoid's ability to evolve towards increased success on a given host simultaneously with the evolution of the composition of its venom has never been demonstrated. Here, we designed an experimental...
Uploaded on: December 3, 2022 -
2013 (v1)Journal article
Endoparasitoid wasps develop at the expense of other insects, leading to their death. Eggs deposited inside the host body induce an immune response, which results in the formation of a melanized cellular capsule around the egg. To evade or counteract this response, endoparasitoids have evolved different strategies, the most often reported being...
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2013 (v1)Journal article
The arms race between immune suppressive parasites that produce virulence factors and hosts that evolve resistance to these factors is suggested to be a key driver for the diversification of both partners. However, little is known regarding the diversity of virulence factors in closely related parasites or the mechanisms underlying the...
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2014 (v1)Journal article
Endoparasitoid wasps are essential regulators of insect pests in ecosystems as well as important biological control auxiliaries. Traits important for parasitism success, such as the injection of venom proteins at oviposition, have thus been mainly studied. However, identification of the key genes involved among the large number of genes...
Uploaded on: December 4, 2022 -
March 23, 2015 (v1)Conference paper
National audience
Uploaded on: December 4, 2022 -
November 15, 2012 (v1)Conference paper
National audience
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October 2, 2011 (v1)Conference paper
International audience
Uploaded on: December 4, 2022 -
2017 (v1)Journal article
Aspartylglucosaminidase (AGA) is a low-abundance intracellular enzyme that plays a keyrole in the last stage of glycoproteins degradation, and whose deficiency leads to humanaspartylglucosaminuria, a lysosomal storage disease. Surprisingly, high amounts of AGAlikeproteins are secreted in the venom of two phylogenetically distant hymenopteran...
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2019 (v1)Journal article
Differentiation of traits among populations can evolve by drift when gene flow is low relative to drift or selection when there are different local optima in each population (heterogeneous selection), whereas homogeneous selection tends to prevent evolution of such a differentiation. Analyses of geographical variations in venom composition have...
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March 4, 2013 (v1)Conference paper
International audience
Uploaded on: December 4, 2022 -
2019 (v1)Publication
Parasitoid wasps rely primarily on venom to suppress the immune response and regulate the physiology of their host. Intraspecific variability of venom protein composition has been documented in some species, but its evolutionary potential is poorly understood. We performed an experimental evolution initiated with crosses of two lines of...
Uploaded on: December 4, 2022 -
August 28, 2012 (v1)Conference paper
Les endoparasitoïdes pondent à l ' intérieur d 'un insecte hôte dans lequel ils se développent, entraînant sa mort. Leur succès reproducteur dépend donc de leur capacité à contrôler l'immunité et la physiologie de l'hôte (Dupas et al. 2003). Les stratégies utilisées font notamment appel à l'injection de facteurs de virulence lors de la ponte,...
Uploaded on: December 4, 2022 -
2010 (v1)Journal article
We have identified and characterized a Macrophage Migration Inhibitory Factor (MIF) family member in the Lophotrochozoan invertebrate, Biomphalaria glabrata, the snail intermediate host of the human blood fluke Schistosoma mansoni. In mammals, MIF is a widely expressed pleiotropic cytokine with potent pro-inflammatory properties that controls...
Uploaded on: December 3, 2022 -
2019 (v1)Journal article
Abstract: Parasitoid wasps rely primarily on venom to suppress the immune response and regulatethe physiology of their host. Intraspecific variability of venom protein composition has beendocumented in some species, but its evolutionary potential is poorly understood. We performed anexperimental evolution initiated with the crosses of two lines...
Uploaded on: December 4, 2022 -
June 8, 2023 (v1)Publication
Animal venoms and other protein-based secretions that perform a variety of functions, from predation to defense, are highly complex cocktails of bioactive compounds. Gene duplication, accompanied by modification of the expression and/or function of one of the duplicates under the action of positive selection, followed by further duplication to...
Uploaded on: June 10, 2023