C

J

COLL , Jean

Last name: COLL

First name: Jean

August 2006 (v1)

Journal article

Metadata-only

Autoactivation of the Epstein-Barr virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-kappaB and JNK signaling pathways.

Goormachtigh, Gautier Ouk, Tan-Sothea Mougel, Alexandra

Epstein-Barr virus (EBV) is associated with several human malignancies where it expresses limited subsets of latent proteins. Of the latent proteins, latent membrane protein 1 (LMP1) is a potent transforming protein that constitutively induces multiple cell signaling pathways and contributes to EBV-associated oncogenesis. Regulation of LMP1...

Uploaded on: December 3, 2022
April 2012 (v1)

Journal article

Metadata-only

EBV Latency II-derived Peptides Induce A Specific CD4+ Cytotoxic T-cell Activity and Not A CD4+ Regulatory T-cell Response

Moralès, Olivier Depil, Stéphane Mrizak, Dhafer

Epstein-Barr virus (EBV) is associated with several malignant diseases that can be distinguished by their patterns of viral latent gene expression. We developed here an original peptidic approach to favor the induction of a specific CD4+ T-cell response against EBV latency II malignancies (Hodgkin's lymphoma, nasopharyngeal carcinoma, T/NK...

Uploaded on: December 4, 2022