COLUCCI D'AMATO , L.

Glioblastoma multiforme is a highly aggressive brain tumor whose prognosis is very poor. Due to early invasion of brain parenchyma, its complete surgical removal is nearly impossible, and even after aggressive combined treatment (association of surgery and chemo- and radio-therapy) five-year survival is only about 10%. Natural products are...

Activation of microglia is a central event in the atypical inflammatory response occurring during prion encephalopathies. We report that the prion protein fragment encompassing amino acids 90-231 (PrP90-231), a model of the neurotoxic activity of the pathogenic prion protein (PrP(Sc)), causes activation of both primary microglia cultures and N9...

Tau is a multifunctional protein detected in different cellular compartments in neuronal and non-neuronal cells. When found hyperphosphorylated and aggregated in atrophic neurons, is considered the culprit for neuronal death in familial and sporadic tauopathies. In Alzheimer's disease (AD) it is instead debated whether entangled tau...