C

C

CONTADINI , Claudia

Last name: CONTADINI

First name: Claudia

2023 (v1)

Publication

Metadata-only

Identification and Biological Characterization of the Pyrazolo[3,4-d]pyrimidine Derivative SI388 Active as Src Inhibitor

Contadini, Claudia Cirotti, Claudia Carbone, Anna

Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or Bcr-Abl TK inhibitors and performed a lead optimization study to discover a new generation...

Uploaded on: February 14, 2024