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CORDEIRO-DA-SILVA A.

Last name: CORDEIRO-DA-SILVA A.

2024 (v1)

Publication

Metadata-only

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents

Francesconi V. Rizzo M. Pozzi C.

Folate enzymes, namely, dihydrofolate reductase (DHFR) and pteridine reductase (PTR1) are acknowledged targets for the development of antiparasitic agents against Trypanosomiasis and Leishmaniasis. Based on the amino dihydrotriazine motif of the drug Cycloguanil (Cyc), a known inhibitor of both folate enzymes, we have identified two novel...

Uploaded on: August 29, 2024