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CORMERAIS , Yann

Last name: CORMERAIS

First name: Yann

July 22, 2016 (v1)

Publication

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Amino acids and cancer : LAT1, a transporter essential for mTORC1 activity and tumor growth

Cormerais, Yann

Tumours rely on external amino acids (AA) uptake to maintain their exacerbated metabolism and proliferation. To optimize AA uptake, tumors overexpress key carriers such as the multifunctional CD98/LAT 1 heterodimer. CD98 (SLC3A2) acts as a co-receptor of β integrins and enhances signaling that promotes cellular migration and invasion. LAT1...

Uploaded on: February 28, 2023
December 17, 2019 (v1)

Journal article

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Targeting amino acids transporters (SLCs) to starve cancer cells to death

Cormerais, Yann Vucetic, Milica Pouysségur, Jacques

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Uploaded on: December 3, 2022
August 20, 2015 (v1)

Journal article

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Resistance to sunitinib in renal clear cell carcinoma results from sequestration in lysosomes and inhibition of the autophagic flux

Giuliano, Sandy Cormerais, Yann Dufies, Maeva

Metastatic renal cell carcinomas (mRCC) are highly vascularized tumors that are a paradigm for the treatment with antiangiogenesis drugs targeting the vascular endothelial growth factor (VEGF) pathway. The available drugs increase the time to progression but are not curative and the patients eventually relapse. In this study we have focused our...

Uploaded on: December 4, 2022