CORMONT , Mireille

International audience

Alteration of adipocyte function plays a key role in the pathogenesis of metabolic diseases such as insulin resistance and Type 2 Diabetes. This highlights the need to better understand the molecular mechanism involved in adipocyte dysfunction in order to develop new therapies against obesity-related diseases. Manipulating the expression of...

Abstract Background The trafficking of cargoes from endosomes to the trans -Golgi network requires numerous sequential and coordinated steps. Cargoes are sorted into endosomal-derived carriers that are transported, tethered, and fused to the trans -Golgi network. The tethering step requires several complexes, including the Golgi-associated...

Background and aims: Obesity is a major risk factor for metabolic diseases including insulin resistance (IR) and Type 2 Diabetes (T2D). Excessive expansion of white adipose tissue (WAT) during obesity is accompanied by macrophage accumulation. Metabolic stress in obese adipose tissue (AT) modifies the function and fate of AT macrophages (ATMs),...

Inflammation is associated with obesity and insulin resistance. Proinflammatory cytokines produced by adipose tissue in obesity could alter insulin signaling and action. Recent studies have shown a relationship between IL-1beta level and metabolic syndrome or type 2 diabetes. However, the ability of IL-1beta to alter insulin signaling and...

Metabolic stresses alter the signaling and actions of insulin in adipocytes during obesity, but the molecular links remain incompletely understood. Members of the microRNA-34 (miR-34 family play a pivotal role in stress response, and previous studies showed an upregulation of miR-34a in adipose tissue during obesity. Here, we identified miR-34a...

Metabolic stresses alter the signaling and actions of insulin in adipocytes during obesity, but the molecular links remain incompletely understood. Members of the microRNA-34 (miR-34 family play a pivotal role in stress response, and previous studies showed an upregulation of miR-34a in adipose tissue during obesity. Here, we identified miR-34a...

Obesity is a major worldwide public health issue that increases the risk to develop cardiovascular diseases, type-2 diabetes, and liver diseases. Obesity is characterized by an increase in adipose tissue (AT) mass due to adipocyte hyperplasia and/or hypertrophia, leading to profound remodeling of its three-dimensional structure. Indeed, the...