C
E
Last name: COSSON
First name: Estelle
Institution: UCA
Links
a Y.G. and M.B. contributed equally to this work b T.M. and V.M.B. contributed equally to this work ORCIDs M. Goncalves-Maia: 0000-0002-9975-0180 Y. Gache: 0000-0002-5638-4854
The integrative analysis of tumor immune microenvironment (TiME) components, their interactions and their microanatomical distribution is mandatory to better understand tumor progression. Imaging Mass Cytometry (IMC) is a high dimensional tissue imaging system which allows the comprehensive and multiparametric in situ exploration of tumor...
Cutaneous squamous cell carcinoma (cSCC) development has been linked to immune dysfunctions but the mechanisms are still unclear. Here, we report a progressive infiltration of tumor-associated neutrophils (TANs) in precancerous and established cSCC lesions from chemically induced skin carcinogenesis. Comparative in-depth gene expression...
Co-stimulatory and inhibitory receptors expressed by immune cells in the tumor microenvironment modulate the immune response and cancer progression. Their expression and regulation are still not fully characterized and a better understanding of these mechanisms is needed to improve current immunotherapies. Our previous work has identified a...
Senescent cells accumulate in aging tissues, and their elimination can favor healthy aging 1-4 . Therefore, therapeutic interventions targeting cellular senescence may be promising strategies for delaying or reversing a vast range of age-related diseases 5 . As cells of the immune system are responsible for senescent cell elimination 6-11 , a...