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COSTANZI , Marco

Last name: COSTANZI

First name: Marco

2013 (v1)

Publication

Metadata-only

Infusion of 2.5 meq/min of lactic acid minimally increases CO2 production compared to an isocaloric glucose infusion in healthy anesthetized, mechanically ventilated pigs

Zanella, Alberto Giani, Marco Redaelli, Sara

Introduction: Blood acidification by lactic acid infusion converts bicarbonate to CO2. This effect can be exploited to increase the transmembrane PCO2 gradient of an extracorporeal membrane lung, resulting in a significant increase of extracorporeal CO2 removal. Lactic acid, however, is an energetic substrate and its metabolism might increase...

Uploaded on: April 14, 2023
2009 (v1)

Publication

Metadata-only

Blood acidification enhances carbon dioxide removal of membrane lung: An experimental study

Zanella, Alberto Patroniti, Nicolò Isgrò, Stefano

Purpose: Extracorporeal CO2removal is an effective procedure to allow a protective ventilatory strategy in ARDS patients, but it is technically challenging due to the high blood flow required. Increasing the CO2transfer through the membrane lung (ML) may lower the demand of extracorporeal blood flow and consequently allow for a wider clinical...

Uploaded on: April 14, 2023