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COVINHES , Aurélie

Last name: COVINHES

First name: Aurélie

2017 (v1)

Journal article

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Acute and long-term cardioprotective effects of the Traditional Chinese Medicine MLC901 against myocardial ischemia-reperfusion injury in mice

Vincent, Anne Covinhes, Aurélie Barrère, Christian

MLC901, a traditional Chinese medicine containing a cocktail of active molecules, both reduces cerebral infarction and improves recovery in patients with ischemic stroke. The aim of this study was to evaluate the acute and long-term benefits of MLC901 in ischemic and reperfused mouse hearts. Ex vivo, under physiological conditions, MLC901 did...

Uploaded on: December 3, 2022
August 2023 (v1)

Journal article

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Heart rate reduction after genetic ablation of L-type Cav1.3 channels induces cardioprotection against ischemia-reperfusion injury

Delgado-Betancourt, Viviana Chinda, Kroekkiat Mesirca, Pietro

Background: Acute myocardial infarction (AMI) is the major cause of cardiovascular mortality worldwide. Most ischemic episodes are triggered by an increase in heart rate, which induces an imbalance between myocardial oxygen delivery and consumption. Developing drugs that selectively reduce heart rate by inhibiting ion channels involved in heart...

Uploaded on: September 5, 2023