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CRUZ-DUARTE , Raquel

Last name: CRUZ-DUARTE

First name: Raquel

March 15, 2022 (v1)

Journal article

Metadata-only

Predictive and therapeutic implications of a novel PLCγ1/SHP2-driven mechanism of cetuximab resistance in metastatic colorectal cancer.

Cruz-Duarte, Raquel de Almeida, Cátia Negrão, Magda

Purpose: Cetuximab is an EGFR-targeted therapy approved for the treatment of RAS wild-type (WT) metastatic colorectal cancer (mCRC). However, about 60% of these patients show innate resistance to cetuximab. To increase cetuximab efficacy, it is crucial to successfully identify responder patients, as well as to develop new therapeutic approaches...

Uploaded on: December 4, 2022