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CSIZMADIA , Eva

Last name: CSIZMADIA

First name: Eva

2015 (v1)

Publication

Metadata-only

N-WASP is required for B-cell-mediated autoimmunity in Wiskott-Aldrich syndrome

Volpi, Stefano Santori, Elettra Abernethy, Katrina

Mutations of the Wiskott-Aldrich syndrome gene (WAS) are responsible for Wiskott- Aldrich syndrome (WAS), a disease characterized by thrombocytopenia, eczema, immunodeficiency, and autoimmunity. Mice with conditional deficiency of Was in B lymphocytes (B/WcKO) have revealed a critical role for WAS protein (WASP) expression in B lymphocytes in...

Uploaded on: April 14, 2023
2012 (v1)

Publication

Metadata-only

B cell-intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice

Recher, Mike Burns, Siobhan O. De La Fuente, Miguel A.

Wiskott Aldrich syndrome (WAS) is caused by mutations in the WAS gene that encodes for a protein (WASp) involved in cytoskeleton organization in hematopoietic cells. Several distinctive abnormalities of T, B, and natural killer lymphocytes; dendritic cells; and phagocytes have been found in WASp-deficient patients and mice; however, the in vivo...

Uploaded on: March 27, 2023