D'ARRIGO C.

Last name: D'ARRIGO C.

2012 (v1)

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Differential toxicity, conformation and morphology of typical initial aggregation states of Aβ1-42 and Aβpy3-42 beta-amyloids

GALANTE, DENISE CORSARO, ALESSANDRO FLORIO, TULLIO

Among the different species of water-soluble beta-peptides (Abeta1-42, Abeta1-40 and N-terminal truncated Abeta-peptides), Abetapy3-42 is thought to play a relevant role in Alzheimer's pathogenesis due to its abundance, resistance to proteolysis, fast aggregation kinetics, dynamic structure and high neurotoxicity. To evaluate the specific...

Uploaded on: April 14, 2023
2019 (v1)

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Biophysical and in Vivo Studies Identify a New Natural-Based Polyphenol, Counteracting Aβ Oligomerization in Vitro and Aβ Oligomer-Mediated Memory Impairment and Neuroinflammation in an Acute Mouse Model of Alzheimer's Disease

Tomaselli S. La Vitola P. Pagano K.

In this study natural-based complex polyphenols, obtained through a smart synthetic approach, have been evaluated for their ability to inhibit the formation of Aβ42 oligomers, the most toxic species causing synaptic dysfunction, neuroinflammation, and neuronal death leading to the onset and progression of Alzheimer's disease. In vitro...

Uploaded on: April 14, 2023
2010 (v1)

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Study of the Molecular Mechanism Responsible of the Conformational Changes Induced by E200K and D202N Pathological PrP Mutation

CORSARO, ALESSANDRO THELLUNG DE COURTELARY, STEFANO VILLA, VALENTINA

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Uploaded on: March 31, 2023

D'ARRIGO C.

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