2021 (v1)
Publication
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Uploaded on: April 14, 2023
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2021 (v1)PublicationBNCT: development of a novel Boron Delivery Antibody (BDA) by means of specific residues replacement
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2021 (v1)Publication
Boron Neutron Capture Therapy (BNCT) is a tumor cell-selective radiotherapy based on a nuclear reaction that occurs when the isotope boron-10 (10B) is radiated by low-energy thermal neutrons or epithermal neutrons, triggering a nuclear fission response and enabling a selective administration of irradiation to cells. Hence, we need to create...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
Cystic fibrosis transmembrane conductance regulator (CFTR)-rescuing drugs have already transformed cystic fibrosis (CF) from a fatal disease to a treatable chronic condition. However, new-generation drugs able to bind CFTR with higher specificity/anity and to exert stronger therapeutic benefits and fewer side eects are still awaited....
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2020 (v1)Publication
Cystic Fibrosis (CF) is caused by mutations (mainly F508del) of the cystic fibrosis transmembrane conductance regulator (CFTR). Current CF therapies are aimed at symptoms alleviation, calling for new drugs to rescue CFTR function. Hypothesis and objectives Drug repositioning is aimed at finding new applications for already marketed drugs,...
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2019 (v1)Publication
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2013 (v1)Publication
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2022 (v1)Publication
Cystic fibrosis is a hereditary disease mainly caused by the deletion of the Phe 508 (F508del) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome system. Cystic fibrosis remains a potentially fatal disease, but it has...
Uploaded on: November 25, 2023 -
2019 (v1)Publication
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Uploaded on: April 14, 2023