February 27, 2015 (v1)
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Uploaded on: March 27, 2023
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December 5, 2023 (v1)Publication
La presente invención se refiere a una composición farmacéutica que comprende el compuesto N-fenil-N- (3-metil-2-butenil)tiourea y al uso del compuesto Nfenil-N-(3-metil-2-butenil)tiourea y de dicha composición farmacéutica en la elaboración de medicamentos destinados al tratamiento de enfermedades que cursan con hiperamoniemia, como por...
Uploaded on: December 7, 2023 -
March 10, 2016 (v1)Publication
Ammonia production is implicated in the pathogenesis of hepatic encephalopathy (HE), being intestinal glutaminase activity the main source for ammonia. Management of ammonia formation can be effective in HE treatment by lowering intestinal ammonia production. The use of glutaminase inhibitors represents one way to achieve this goal. In this...
Uploaded on: March 27, 2023 -
February 2, 2015 (v1)Publication
Aim: To investigate the influence of metformin use on liver dysfunction and hepatic encephalopathy in a retrospective cohort of diabetic cirrhotic patients. To analyze the impact of metformin on glutaminase activity and ammonia production in vitro. Methods: Eighty-two cirrhotic patients with type 2 diabetes were included. Forty-one patients...
Uploaded on: March 27, 2023