D. CALZIA

Myelin proteomics has been the subject of intense research over the last decade, and its profiling has achieved good results by both in-gel and mass spectrometry-based techniques. 1280 proteins have been identified, a number expected to increase. Some of the identified proteins are as yet not established as true components of myelin. There...

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Purpose Oxidative stress is involved in retinal diseases such as diabetic retinopathy, age-related macular degeneration and retinal damage by light, characterized by Reactive Oxygen Intermediates (ROI) production. Rod Outer Segments (OS), display a mitochondria-like activity, producing ATP and consuming oxygen through the expression of the...

Cyclic ADP-ribose (cADPR) is a second messenger modulating intracellular calcium levels. We have previously described a cADPR-dependent calcium signaling pathway in bovine rod outer segments (ROS), where calcium ions play a pivotal role. ROS ADP-ribosyl cyclase (ADPR-cyclase) was localized in the membrane fraction. In the present work, we...

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