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1995 (v1)PublicationUploaded on: April 14, 2023
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2012 (v1)Publication
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2009 (v1)Publication
he epidermal growth factor receptor (EGFR) is a transmembrane tyrosine kinase receptor involved in the proliferation and survival of cancer cells. EGFR is the first molecular target against which monoclonal antibodies (mAb) have been developed for cancer therapy. Here we review the mechanisms underlying the effects of EGFR-specific mAb in...
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2000 (v1)Publication
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2000 (v1)Publication
Asthma is a complex inflammatory disease of the lung characterized by variable airflow obstruction, bronchial hyperresponsiveness, and airway inflammation. Inflammation in asthma consists of airway infiltration by mast cells, lymphocytes, and eosinophils. There is accumulating evidence that CD4+ lymphocytes with a Th2-cytokine pattern play a...
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2000 (v1)Publication
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2009 (v1)Publication
Human Th17 clones and circulating Th17 cells showed lower susceptibility to the antiproliferative effect of TGF-b than Th1 and Th2 clones or circulating Th1-oriented T cells, respectively. Accordingly, human Th17 cells exhibited lower expression of clusterin, and higher Bcl-2 expression and reduced apoptosis in the presence of TGF-b,...
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2011 (v1)Publication
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1997 (v1)Publication
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2011 (v1)Publication
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2009 (v1)Publication
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2010 (v1)Publication
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2007 (v1)Publication
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2017 (v1)Publication
Vaccines play a primary role in the protection of human health by preventing infectious and chronic diseases. Recently we have reported 1,2-O-distearoyl-3-O-β-d-sulfoquinovosylglycerol (β-SQDG18), here named Sulfavant A (1), which shows promising properties as a new molecular adjuvant in in vitro and in vivo tests. In the present manuscript, we...
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2011 (v1)Publication
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2000 (v1)Publication
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2017 (v1)Publication
In the last twenty years, our comprehension of the molecular mechanisms involved in the formation, progression and complication of atherosclerotic plaque has advanced significantly and the main role of inflammation and immunity in this phenomenon is now largely accepted. Accumulating evidence highlight the crucial role of different inflammatory...
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2005 (v1)Publication
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