DEFRANCHI E

Predicting off-targets by computational methods is getting increasing importance in early drug discovery stages. We herewith present a computational method based on binding site three-dimensional comparisons, which prompted us to investigate the cross-reaction of protein kinase inhibitors with synapsin I, an ATP-binding protein...

It is generally accepted that the Ca2-dependent interaction of calpain with calpastatin is the most relevant mechanism involved in the regulation of Ca2-induced proteolysis.Wenow report that a calpain-calpastatin association can occur also in the absence of Ca2 or at very low Ca2 concentrations, reflecting the physiological conditions under...

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