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DADONE-MONTAUDIE , Bérengère

Last name: DADONE-MONTAUDIE

First name: Bérengère

December 2020 (v1)

Journal article

Metadata-only

High throughput profiling of undifferentiated pleomorphic sarcomas identifies two main subgroups with distinct immune profile, clinical outcome and sensitivity to targeted therapies

Toulmonde, Maud Lucchesi, Carlo Verbeke, Stéphanie

Background: Undifferentiated pleomorphic sarcoma (UPS) is the most frequent, aggressive and less-characterized sarcoma subtype. This study aims to assess UPS molecular characteristics and identify specific therapeutic targets. Methods: High-throughput technologies encompassing immunohistochemistry, RNA-sequencing, whole exomesequencing, mass...

Uploaded on: December 4, 2022
April 8, 2022 (v1)

Publication

Metadata-only

Abstract 2578: High regulatory T cells infiltrate within tertiary lymphoid structure restricts response to immune checkpoint blockers in sarcomas

Peyraud, Florent Guegan, Jean-Philippe Rey, Christophe

Abstract Background: While composition of the tumor microenvironment (TME) is a prerequisite for an effective antitumor immunity, infiltration of organized B- and T-cells aggregates called tertiary lymphoid structures (TLS) has been recently demonstrated to predict response to immune checkpoint blockers (ICB) in sarcomas. However, only a...

Uploaded on: September 12, 2024