The need of reliable syngeneic animal models for gliomas has been addressed in the last decades by reproducing genetic alterations typical of human glioblastoma in the mouse. Since different alterations underlie different molecular glioblastoma subtypes it is commonly expected that tumors induced by specific alterations represent models of the...
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2019 (v1)PublicationUploaded on: April 14, 2023
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2023 (v1)Publication
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Uploaded on: October 4, 2024 -
2019 (v1)Publication
Oncolytic herpes simplex viruses are proving to be effective in clinical trials against a number of cancers. Here, R-115, an oncolytic herpes simplex virus retargeted to human erbB-2, fully virulent in its target cells, and armed with murine interleukin-12 was evaluated in a murine model of glioblastoma. We show that a single R-115 injection in...
Uploaded on: April 14, 2023 -
2020 (v1)Publication
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Uploaded on: April 14, 2023